Agriculture Reference
In-Depth Information
Duration not specifi ed but at
least 3.5 months (14 weeks)
Dams and their offsprings fed
with the diets during the
periods of mating, gestation,
lactation, offspring care and
pubescence.
F3 rats fed until they reached 3.5
months in age.
F0 + 3 generations
Bt 176 (
cry1Ab
gene)
Sheep
(53 Bergamasca × Appenninica
ewes and their progeny for 3
years)
Immune response, ruminal
metabolism, microbial
population, meat quality,
microscopy, transgene
detection.
Differences only observed in
some cytosolic observations
(liver and pancreas cell nuclei)
and immune response to
Salmonella vaccination.
Signifi cance and reproducibility
of these phenomena unclear.
Small effects. Suggestion for
more metabolic research, in
particular in gastrointestinal
organs and the immune
response mechanisms.
Trabalza-Marinucci
et al
., 2008
44 months (188 weeks)
F0 + 3 generations
Bt 11 (
cry1Ab
)
gene
Mice
(F0: 99 females, 117 males fed
non-GM maize; 108 females
and 108 males fed GM maize.
F1: 21 females and 17 males fed
non-GM maize; 52 females
and 55 males fed GM maize)
Growth. Gestation, milking
periods, reproduction, lifespan.
Breeding performance in 4
generations.
No difference in any parameters.
Safe, no multi-generational
effects.
Haryu
et al
., 2009
Organ weight: 16 GM-fed mice
and 22 non-GM;
Lifespan: 45 GM-fed mice and 44
non-GM mice
