Agriculture Reference
In-Depth Information
Table 8.2.
Compilation of multi-generational animal feeding studies.
Animal species (animal number
per group and duration)
Plant species/trait
Parameters
Main results
Authors' interpretation of results
Reference
Maize
Bt 11 (38PO6),
non-transgenic
control (38PO5)
Mice
(10 females per diet),
(3 males chosen in progeny for
each of six time points),
8, 16, 26, 32, 63 and 87 days
after birth (from approximately
1 week to approximately 12
weeks)
4 generations
Testicular development, litter size,
body weight.
No differences in fetal, postnatal,
pubertal, or adult testicular
development with the GM diet.
Safe, no multi-generational
effects.
Brake
et al
., 2004
Bt 176
(
cry1Ab
gene)
Quails
(weeks 1-6: 70 males, 75
females; weeks 7-12: 32
hens)
Growing (6 weeks), laying
performance, reproduction,
hatchability (210 eggs per
hatch).
No biologically relevant infl uence
on growth, laying performance
and hatchability.
Safe, no multi-generational
effects.
Flachowsky
et al
.,
2005;
Flachowsky
et al
.,
2007
10
12 weeks; 840 days
10 generations
Bt 176 (
cry1Ab
gene)
Laying hens
(weeks 1-18: 36; weeks 19-31:
18)
4
31 weeks; 868 days
4 generations
Growing (18 weeks), laying
performance, hatchability.
No signifi cant differences in
growth, laying performance
and hatchability.
Safe, no multi-generational
effects.
Halle
et al
., 2006
Bt (event not
specifi ed)
Wistar albino rats
Histological and biochemical
parameters characterizing
stomach, duodenum, liver,
kidney.
No differences in organ weights.
Some minor histological
changes in liver and kidney
(change in creatinine, total
Changes are minor and do not
threaten the health of rats.
Suggestion that long-term
feeding studies be performed
Kiliç and Akay, 2008
(F0: 18 females, 6 rats/each
group, mated with 9 males,
