Respiratory and Cardiovascular Effects of Metals in Ambient Particulate Matter: A Critical Review - Reviews of Environmental Contamination and Toxicology - page 174

Concentrations in ʼ g metal/mg ROFA extract (ratio of animal dose to human on body wt basis) a

Outcomes and indicators
of effect evaluated Sources Fe Mn Ni V Zn

Lambert et al. ( 2000 )
ROFA
(power plant in Florida)

51.3 (13,000) 0.4 (3,100) 36.6 (660,000) 58.2 (1,200,000) - Infl ammatory cellular

response; Allergic Sensitization

Lewis et al. ( 2003 )
Boston_Mystic Power Plant

(t)122.0 (1,200,000) (t)38.4 (380,000) (t)46.0 (460,000) (t)5.34 (53,000) Infl ammatory cellular

response; reactive oxygen
species

(s)18.6 (190,000) (s)27.9 (280,000) (s)0.58 (5,800) (s)4.34 (43,000)

(i)93.2 (930,000) (i)5.5 (55,000) (i)41.6 (420,000) (i)0.56 (5,600)

Nadadur et al. (2002)
ROFA
(power plant in Florida)

51.300 (13,000) 0.4 (3,100) 36.6 (650,000) 58.2 (1,200,000) - Cardiovascular effects

Roberts et al. ( 2004 )
Precipitator (t)122.0 (91,000) - (t)38.4 (2,100,000) (t)46.0 (2,900,000) (t)5.34 (27,000) Cellular infl ammatory

response; Bacterial Clearance

Boston_Mystic Power Plant (s)18.6 (14,000) (s)27.9 (1,500,000) (s)0.58 (37,000) (s)4.34 (22,000)

(i)93.2 (69,000) (i)5.5 (300,000) (i)41.6 (2,600,000) (i)0.56 (2,800)

Wallenborn et al. ( 2007 )
HP-12 Boston Power Plant

(t)47.0 (390,000) (t)0.56 (4,600) (t)43.1 (360,000) (t)62.95 (520,000) (t)29.86

(250,000)

Metal translocation

(s)1.09 (9,000) (s)0.31 (2,600) (s)6.61 (55,000) (s)7.18 (60,000) (s)11.55

(96,000)

(hcl)13.74 (110,000) (hcl)0.13

(1,100)

(hcl)9.12 (76,000) (hcl)26.5 (220,000) (hcl)6.62

(55,000)

(i)32.21 (270,000) (i)0.12 (1,000) (i)27.37 (230,000) (i)29.27 (240,000) (i)11.69 (97,000)

a Dose expressed as ratio of animal to man on body weight basis, based on STN annual means (Table 3 ), body mass = 70 kg, 10 kg, 0.3 kg and 0.02 kg for man, dog, rat and
mouse, respectively, and volume of air breathed/day = 10 m 3 , 1 m 3 , 0.262 m 3 , and 0.01 m 3 for man, dog, rat and mouse, respectively
b Authors do not provide mass of PM aerosolization rate, making it impossible to calculate ratio of dose to ambient
c Animal/man dosage ratios shown in parentheses are based on the lowest dose of 0.83 mg/kg; multiply ratios by 10 to correspond to the highest dose of 8.3 mg/kg
d Animal/man dosage ratios shown in parentheses are based on the lowest dose of 0.83 mg/kg; multiply ratios by 4 to correspond to the highest dose of 3.33 mg/kg
(t)—total; (i)—insoluble fraction; (s)—soluble fraction; (hcl)—acid soluble