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the methods and implications of skeletal muscle fiber subtypes, the develop-
ment of automated image-analysis programs for analyzing skeletal muscle,
and we present evidence that TRMU, a protein likely involved in mito-
chondrial
function is expressed, preferentially,
in Type I
skeletal
muscle fibers.
As high-content imaging, whole slide scanning, and digital pathology
methods come of age, advanced image databases such as the Human Protein
Atlas will increasingly serve as testing grounds for novel automated image-
analysis methods. By seamlessly interfacing these automated methods with
the world-wide social network of computational biologists and biomedical
researchers, many synergistic advances in our understanding of this funda-
mentally important and fascinating tissue can be greatly accelerated.
ACKNOWLEDGMENTS
We thank Natalie Prigozhina of Vala Sciences Inc. for her help in preparing figures regarding
skeletal muscle structure and mitochondrial metabolism. We thank Behrad Azimi of Vala
Sciences Inc. for encoding the MATLAB program for downloading and viewing images
from the Human Protein Atlas. Funding for this project was partially provided by NIH/
NIAMS STTR grant R42AR055604-03 “Automated Analysis of Skeletal Muscle Fiber
Cross-sectional Area and Metabolic Type.”
REFERENCES
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