New Insights into the Role of BubR1 in Mitosis and Beyond - International Review of Cell and Molecular Biology - page 259

desirable and might reveal perhaps subtle tissue-specific developmental
defects not visible in cultured cells. Finding new partners and regulatory
cofactors of BubR1 may also give new insights into how BubR1 is regulat-
ing these various cellular processes. Identifying small-molecule inhibitors
would help decipher the pleiotropic roles of BubR1 in the cell. This may
also open new opportunities for treatment of cancer that could be used in
combination with chemical agents that damage DNA. Clearly, there is still
a lot of work that needs to be done to unravel the cellular roles of BubR1,
but there is no doubt that the future will bring new clues that will help
resolve these mysteries and controversies.
ACKNOWLEDGMENTS
Work by Z. R. and R. E. K. was supported by the program “Equipe Labellis ´ e Ligue Contre
le Cancer” and the Centre National de la Recherche Scientifique (CNRS). The lab is a
member of the French Laboratory of Excellence Program No. ANR-11-LABX-0071/
Investments for the Future Program No. ANR-11-IDEX-0005-01. Work by K. W. was
supported by ANR Grant ANR-12-BSV2-0005-01.
REFERENCES
Abrieu, A., Kahana, J.A., Wood, K.W., Cleveland, D.W., 2000. CENP-E as an essential
component of the mitotic checkpoint in vitro. Cell 102, 817-826.
Ando, K., Kakeji, Y., Kitao, H., Iimori, M., Zhao, Y., et al., 2010. High expression of
BUBR1 is one of the factors for inducing DNA aneuploidy and progression in gastric
cancer. Cancer Sci. 101, 639-645.
Andrews, P.D., Ovechkina, Y., Morrice, N., Wagenbach, M., Duncan, K., et al., 2004.
Aurora B regulates MCAK at the mitotic centromere. Dev. Cell 6, 253-268.
Baker, D.J., Jeganathan, K.B., Cameron, J.D., Thompson, M., Juneja, S., et al., 2004.
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility
in mice. Nat. Genet. 36, 744-749.
Basu, J., Logarinho, E., Herrmann, S., Bousbaa, H., Li, Z., et al., 1998. Localization of the
Drosophila checkpoint control protein Bub3 to the kinetochore requires Bub1 but not
Zw10 or Rod. Chromosoma 107, 376-385.
Bie, L., Zhao, G., Cheng, P., Rondeau, G., Porwollik, S., et al., 2011. The accuracy of sur-
vival time prediction for patients with glioma is improved by measuring mitotic spindle
checkpoint gene expression. PLoS One 6, e25631.
Bolanos-Garcia, V.M., Lischetti, T., Matak-Vinkovic, D., Cota, E., Simpson, P.J., et al.,
2011. Structure of a Blinkin-BUBR1 complex reveals an interaction crucial for
kinetochore-mitotic checkpoint regulation via an unanticipated binding site. Structure
19, 1691-1700.
Boyarchuk, Y., Salic, A., Dasso, M., Arnaoutov, A., 2007. Bub1 is essential for assembly of
the functional inner centromere. J. Cell Biol. 176, 919-928.
Brunet, S., Pahlavan, G., Taylor, S., Maro, B., 2003. Functionality of the spindle checkpoint
during the first meiotic division of mammalian oocytes. Reproduction 126, 443-450.
Buffin, E., Lefebvre, C., Huang, J., Gagou, M.E., Karess, R.E., 2005. Recruitment of Mad2
to the kinetochore requires the Rod/Zw10 complex. Curr. Biol. 15, 856-861.