New Insights into the Role of BubR1 in Mitosis and Beyond - International Review of Cell and Molecular Biology - page 229

Acetylation and sumoylation

Mutant phenotype PO 4

in
t axol Notes

Presumed
enzyme

PO 4 in
nocodazole

K250R K250Q

Residue a

References

Acetylated
K250

PCAF
acetylase

Shortened mitotic timing,
premature degradation in prometa,
weaker SAC

SAC
competent

K250Q ¼ acetomimetic Choi et al.

(2009,
2012)

Sumoylated
K250

Acetylation blocks
degradation

Yang et al.
(2012a,b)

a Residues numbers are for human BubR1.