New Insights into the Role of BubR1 in Mitosis and Beyond - International Review of Cell and Molecular Biology - page 227

Table 6.1 Posttranslational modifications of BubR1
Phosphorylation

Mutant phenotype PO 4

in
taxol Notes

PO 4 in
nocodazole

S/T!A S/T!D/E

Residue a Presumed enzyme References

S435 Mps1 Attachment

defect

Yes Huang et al. (2008)

S543 Mps1 ( Huang et al.,

2008 ); Cdk1 ( Elowe
et al., 2010 )

Yes Huang et al. (2008)

and Elowe et al. (2010)

S574 Yes Elowe et al. (2010)

T608 BubR1

autophosphorylation

Yes CenpE

cofactor
dependent

Guo et al. (2012)

S620 Cdk1 Attachment

defect

Yes Priming PO 4

for Plk1

Elowe et al. (2007)

S670 Mps1 ( Huang et al.,

2008 ); Cdk1 ( Elowe
et al., 2010 )

Normal
alignment;
lagging anaphase
chromatids

Normal
alignment;
delayed
anaphase onset

Yes No Attachment-

sensitive,
KARD
domain

Huang et al. (2008) ,
Elowe et al. (2010) ,
and Suijkerbuijk et al.
(2012b)

Continued