Chemistry Reference
In-Depth Information
Fig. 27 (a) Photograph of a tumor-bearing mouse under photothermal treatment. PEGylated
nanocages or saline was administrated intravenously through the tail vein as indicated by an
arrow
. After the NCs had been cleared from the circulation (72 h after injection), the tumor on the
right flank was irradiated with a beam size indicated by the dashed circle. (b-g) Thermographic
images of nanocage-injected (b-e) and saline-injected (f-i) tumor-bearing mice at different time
points: (b, e) 1 min, (c, f) 3 min, (d, g) 5 min, and (e, i) 10 min. (j) Plots of average temperature
within the tumors (
dashed circle
) as a function of irradiation time. All scale bars are 1 cm.
Figure reprinted with kind permission from [
170
]
viability (
10%). This result seems to imply that in addition to the local thermal
effects, significant improvements in NP-mediated PTT can also take advantage of
limiting cellular responses.
<
5.2.4 AuNPs in Radiotherapy
Another method which is widely used to help reduce tumor size is through
radiofrequency. Since the early 1990s, it has been utilized as a treatment for
destroying liver tumors [
189
]. However, this method does have its drawbacks,
