Chemistry Reference
In-Depth Information
pre angiogenesis
post angiogenesis
10
11
10
10
10
9
10
8
10
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10
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10
5
650 nm
808 nm
850 nm
905 nm
10
4
10
3
10
2
(MB)
10
1
0 0 0 0 0 0 0 0 0 0
lateral size of AuNPs / nm
Fig. 23 Molar PA signal intensities as a function of the lateral particle size for the four laser
excitation wavelengths. Error bars indicate the standard deviations evaluated with error propaga-
tion calculations resulting from statistical analysis of STEM micrographs. Lines are drawn to
guide the eyes. Figure adapted from [
150
]
resonance coupling effect of the EGFR-targeted AuNPs [
148
,
149
]. In addition to
that plasmon resonance coupling AuNPs have been suggested for imaging of
macrophages in atherosclerotic plaques for an early detection of cancer [
133
].
In a recent study, Gutrath et al. showed that the molar extinction of spherical
AuNPs with core diameters of 1.0, 1.4, and 11.2 nm, gold nanorods (AuNRs) with
longitudinal/transversal elongation of 38/9 and 44/12 nm, and HAuNs' with outer/
inner diameters of 33/19, 57/30, 68/45, and 85/56 nm can be correlated with the
molar PA signal intensity of the respective AuNPs [
150
]. For increasing lateral
particle size, increasing molar photoacoustic signal intensity is observed, which is
shown in Fig.
23
. The studied AuNPs exhibit significantly larger molar PA
intensities as compared to the commonly used dye MB, except for spherical
Au1.0NPs, which exhibited results comparable to the values of MB. The particle-
size-dependent evaluation of the PA signal intensities is of great interest because
larger particles are useful
to obtain molecular imaging of post-angiogenesis
