Biomedical Engineering Reference
In-Depth Information
(a)
(b)
SCHEME 2.15
Ugi Diels-Alder rearomatization.
eventually eliminates morpholine to give densely substituted pyridine products ( 111 ,
Scheme 2.15b) [44]. A subsequent report demonstrated that oxazole 106 could be
treated with an acid chloride in the presence of a symmetric dienophile to form hex-
asubstituted benzene products after heating. This one-pot process proceeds via furan
113 , which is generated from the elimination of a nitrile to form bicyclic intermediate
115 [46].
 
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