Biomedical Engineering Reference
In-Depth Information
TABLE 18.3
(
Continued
)
Structure
Name
Activity
Assay
Ref.
Oxepane Wntepane 1
Wnt pathway activator;
ED
50
=
Luciferase expressing
reporter cell line
responsive to Wnt3a
96
1.8
M
Indomethacin analog
Angiogenesis-related
receptor tyrosine kinase
inhibitor; IC
50
=
3
M
for Tie-2
Immunosorbent assay of
the amount of
phosphorylated substrate
97
Pochonin analog
Kinase inhibitor; IC
50
=
8
M for Src
Inhibitory activity
against a panel of
kinases
98
Dysidiolide analog
Acetylcholinesterase
inhibitor; IC
50
=
In vitro
spectrophotometric
assay [99]
100
3.7
M
