Biomedical Engineering Reference
In-Depth Information
TABLE 18.3 Representative Natural Product-Inspired Probes Developed from DOS and BIOS
Structure
Name
Activity
Assay
Ref.
,
-Unsaturated
-lactone analog
Entry of vesicular
stomatitis virus
>
3-fold
reduction in infected
cells
Cell-based measure of
viral infection with
VSV-expressing GFP
93
Spirooxindole analog
Inhibition of
microtubule regrowth at
10
M
Phenotypic changes
associated with mitotic
arrest
94
Tetrahydroquinoline
analog
Mycobacterium
tuberculosis
(MTB)
inhibitor; MIC
=
6.25
g/mL
MIC assay
95
(
continued
)
