Biomedical Engineering Reference
In-Depth Information
TABLE 18.2 DOS-Derived Bioactive Small Molecules by Reverse Chemical Genetics
Structure
Name
Activity
Assay
Ref.
Hydroxamic acid tubacin
Tubulin and histone
deacetylase inhibitors;
tubacin increases
Cell-based cytoblot
assays using
acylation-specific
antibodies
30
-tubulin acylation
levels at 125 nM
o
-Aminoanilide histacin
Histacin increases
histone acylation levels
at 20
M
Cell-based cytoblot
assays using
acylation-specific
antibodies
31
