Biomedical Engineering Reference
In-Depth Information
TABLE 18.1
(
Continued
)
Structure
Name
Activity
Assay
Ref.
Polycyclic ketal,
indoline alkaloid, and
guanidine chemotypes
Plasmodium falciparum
inhibitor (antimalaria);
IC
50
=
0.02
M for a
guanidine analog
SYBR green dye DNA
staining assay
23
Fused-bicyclic lactam
analog
Glucose transport
inhibitor; Depletion of
ATP, I C
50
=
1
M
Cell-based assay
determining ATP level
using antimycin
A-sensitized A549 or
CHO cells
24
Naphthyridinone analog
Endothelial cell
activator; activation of
inflammatory pathways
at 10
M
Cellular production of
the chemokine MIP1
25