Biomedical Engineering Reference
In-Depth Information
TABLE 18.1
(
Continued
)
Structure
Name
Activity
Assay
Ref.
Dihydropyrimidine
emmacin
Prokaryote-selective
dihydrofolate reductase
(DHFR) inhibitor; IC
50
=
5.4
M
EMRSA bacterial
proliferation phenotypic
assay
9
Homopiperidine
gemmacin
Cell
membrane-disrupting
antibiotic; MIC
50
=
Minimum inhibitory
concentration (MIC)
assay
10
8.0
g/mL against
EMRSA-15
Furochromane analog
Mycobacterium
tuberculosis
(MTB)
inhibitor; MIC
95
=
0.6
g/mL
Microdilution resazurin
assay
11