Biomedical Engineering Reference
In-Depth Information
TABLE 18.1 DOS-Derived Bioactive Small Molecules by Forward Chemical Genetics
Structure
Name
Activity
Assay
Ref.
Galanthamine analog
secramine
Secretory pathway
inhibitor; blocks protein
trafficking at 2
M
Cell-based phenotypic
assay with VSVG-EGFP
7
Epoxyquinol
BUCMLD-B10A11
Hepatitis C replication
inhibitor; EC
50
<
HCV replicon system
where the HCV
structural genes are
replaced by a luciferase
reporter
8
0.5
M
(
continued
)
