Biomedical Engineering Reference
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(a)
(b)
(c)
FIGURE 2.1 (a) Mitotic spindle kinesin (Eg5) inhibitor monastrol, made by the Biginelli
3CR. (b) Priaxon's MDM2-p53 inhibitor, made by the Shaw 4CR and amide coupling. (c)
Praziquantel ( 11 , Ugi 4CR), GSK's oxytocin antagonist ( 12 , Ugi 4CR), clopidogrel ( 13 , Ugi
3CR and Petasis 3CR), and bicalutamide ( 14 , Passerini 3CR).
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