Biomedical Engineering Reference
In-Depth Information
Hepatic CL
int
In Vivo CL
NF54
Hepatic CL
int
In Vivo CL
NF54
Compound
Mouse
Human
(mL/min/kg)
IC
50
(nM)
Compound
Mouse
Human
(mL/min/kg)
IC
50
(nM)
—
—
—
90
High
High
49.66
9
——
—
20
Low
Low
—
>
5000
SR
-
25
——
—
>
5000
—
—
—
126
SR
-
19
—
—
—
444
Low
Low
9.75
0.9
—
—
—
1808
Low
Low
2.58
77
SS
-
25
SR
-
27