Biomedical Engineering Reference
In-Depth Information
TABLE 17.1 Stereochemical Structure-Activity Relationship
INS-1E Cell Viability
a
(EC
50
,
M)
Configuration
C
2
C
5
C
5
With Cytokines
Without Cytokines
SRR
2.71
IA
RRR
21
IA
SRS
NA
NA
SSR
IA
IA
RRS
26
IA
RSR
IA
IA
SSS
26
IA
RSS
IA
IA
a
IA, inactive; NA, not available.
FIGURE 17.6
Structure of optimized compound
SRR-15
.
