Biomedical Engineering Reference
In-Depth Information
1.11 CONCLUDING REMARKS
In the decade since the DOS concept was introduced, the field has matured consider-
ably, with numerous sophisticated approaches to the generation of molecular diversity
being developed. Emphasis on the generation of scaffold diversity has become inte-
gral to the field, as there is an overriding, and justified, opinion that the incorporation
of this type of diversity into a compound collection is most important in terms of
producing a functionally (biologically) diverse library. As such, many modern exam-
ples focus on the production of compound collections containing a high degree of
three-dimensional scaffold and shape diversity. As the examples highlighted in this
chapter show, the DOS approach has been applied toward the synthesis of a range of
compound collections with varying molecular parameters. In the majority of cases,
the libraries produced are intended to span known drug-like chemical space; however,
as the later examples in this chapter show, the ideas can also be applied effectively to
the synthesis of other structural classes, such as low-molecular-weight fragments or
larger macrocyclic compounds.
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