Biomedical Engineering Reference
In-Depth Information
because of a specific phenotype were revealed to be a powerful tool. Once one or
a few compounds are selected, their mode of action has to be investigated. From a
pharmaceutical point of view, identification of the molecular target both makes it
possible to assess selectivity for the specific target and represents an initial indication
of the possibility of transferring the observed effect to different organisms. In this
case, S. cerevisiae was also shown to be a useful model organism. In conclusion, the
simple yeast model S. cerevisiae represents a good choice both for the selection of
molecules when screening complex compound libraries and for dissection of the way
of action of a selected molecule, thus acting as a beacon along the dark path of drug
discovery (Figure 14.9).
The continuously increasing number, precision and reliability of novel techniques
and the parallel growth of exploitable chemical compound libraries will grant the
possibility to explore previously unpredictable universes with pharmaceutical and
medical interests.
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