Biomedical Engineering Reference
In-Depth Information
polymers were obtained in situ. The polymer array generated was used to screen
against 1700 human embryo stem cells to detect new types of biomaterial, which
could help to modulate stem cell proliferation and differentiation.
13.4 APPLICATIONS OF SMM
One of the most fundamental purposes of biomedical research is to disclose specific
interactions between small molecules and proteins with therapeutic value. After
the identification of potent and selective small molecules for a given therapeutic
protein, the molecule can be further designed and optimized into an inhibitor and
(a)
FIGURE 13.5
Selected examples of SMM construction via in situ synthesis: (a)
fabrication of SMM using orthogonal safety-catch photolabile protective groups;
(b) in situ synthesis of peptoid library via a four-step cycle; (c) in situ synthesis of a dis-
accharide array.
