Biomedical Engineering Reference
In-Depth Information
TABLE 12.1
(
Continued
)
Imaging Assays
Investigating . . .
Descriptive Examples
Literature Examples
Shape/size/number of cells
or cellular structures
Spread-out vs. rounded cell; size or
number of intracellular vesicles;
length, area, or number of
cytoskeletal structures
Invadopodia assay [22];
neurite outgrowth
assay [23]
Cell subpopulation
response
Response of transinfected cells only;
response of one cell type in a mixed
population
Neuronal assay using cell
co-cultures [24]
Multiplexed markers
Multiple cytoskeletal markers;
apoptosis markers probing different
signaling pathways; phophorylated
vs. ubiquitinated vs. acetylated vs.
total protein; differentiation markers
of stem cells
Differentiation of stem
cells into different
lineages [25]
