Biomedical Engineering Reference
In-Depth Information
programs (see Table 11.1). Expanding the palette of DNA-compatible chemical reac-
tions for ad hoc library synthesis, as well as performing selections on protein targets
in native environment (e.g., using living cells or cell lysate), remain the most chal-
lenging tasks for future advances of this technology in the drug discovery field. Only
time will tell whether DNA-encoded chemical library technology will play an impor-
tant role in drug discovery and be able to cope with third-millennium pharmaceutical
challenges [8,129].
Acknowledgments
I would like to thank all the people, research groups, and companies mentioned
above who have provided their exceptional work and experience for the preparation
of this chapter. Particularly, I heartily thank Yixin Zhang for critical reading of the
manuscript and invaluable and inspiring contributions.
REFERENCES
1. S. D. Patterson, R. H. Aebersold,
Nat. Genet.
2003
,
33
, 311-323.
2. R. B. Stoughton,
Annu. Rev. Biochem.
2005
,
74
, 53-82.
3. O. Morozova, M. Hirst, M. A. Marra,
Annu. Rev. Genom. Hum. Genet.
2009
,
10
, 135-151.
4. B. Domon, R. Aebersold,
Science
2006
,
312
, 212-217.
5. R. Kramer, D. Cohen,
Nat. Rev. Drug Discov.
2004
,
3
, 965-972.
6. R. L. Strausberg, S. L. Schreiber,
Science
2003
,
300
, 294-295.
7. J. P. Overington, B. Al-Lazikani, A. L. Hopkins,
Nat. Rev. DrugDiscov.
2006
,
5
, 993-996.
8. V. J. Haupt, M. Schroeder,
Brief. Bioinf.
2011
,
12
, 312-326.
9. T. N. Raju,
Lancet
2000
,
355
, 1022.
10. B. Munos,
Drug Discov.
2009
,
8
, 959-968.
11. P. J. Hajduk, J. Greer,
Nat. Rev. Drug Discov.
2007
,
6
, 211-219.
12. J. Drews,
Science
2000
,
287
, 1960-1964.
13. S. Ghosh, A. Nie, J. An, Z. Huang,
Curr. Opin. Chem. Biol.
2006
,
10
, 194-202.
14. P. Schneider, Y. Tanrikulu, G. Schneider,
Curr. Med. Chem.
2009
,
16
, 258-266.
15. R. A. Houghten, C. Pinilla, S. E. Blondelle, J. R. Appel, C. T. Dooley, J. H. Cuervo,
Nature
1991
,
354
, 84-86.
16. K. S. Lam, S. E. Salmon, E. M. Hersh, V. J. Hruby, W. M. Kazmierski, R. J. Knapp,
Nature
1991
,
354
, 82-84.
17. M. Pellecchia, I. Bertini, D. Cowburn, C. Dalvit, E. Giralt, W. Jahnke, T. L. James, S.
W. Homans, H. Kessler, C. Luchinat, B. Meyer, H. Oschkinat, J. Peng, H. Schwalbe, G.
Siegal,
Nat. Rev. Drug Discov.
2008
,
7
, 738-745.
18. D. C. Rees, M. Congreve, C. W. Murray, R. Carr,
Nat. Rev. Drug Discov.
2004
,
3
,
660-672.
19. D. S. Tan,
Nat. Chem. Biol.
2005
,
1
, 74-84.
20. D. Morton, S. Leach, C. Cordier, S. Warriner, A. Nelson,
Angew. Chem. Int. Ed.
2009
,
48
, 104-109.
