Biomedical Engineering Reference
In-Depth Information
FIGURE 11.20
Example of the chelate effect. High-throughput-sequencing decoding of selection using an ESAC library, containing 120,000
different combinations (i.e., 200
×
600 compounds). Fingerprints revealed a preferential enrichment of compounds (indicated dots, in part a), at the
cross points of three orthogonal lines (part b), thus indicating a simultaneous and cooperative engagement of two adjacent nonoverlapping binding
sites on the same target protein by the two neighboring ESAC pharmacophores.
