Biomedical Engineering Reference
In-Depth Information
M (de novo)
b
Buller et al. 2009
[56]
4,000
DNA conjugate (2)
TNF
20
ETH Z urich/Philochem
AG
11.2.2.1
M (de novo)
b
Buller et al. 2009
[56]
4,000
DNA conjugate (2)
Bcl-xL
10
ETH Z urich/Philochem
AG
11.2.2.1
Hansen et al. 2009
[90]
100
DNA templated
(YoctoReactor)
Anti-enkephalin mAb
Proof of principle
Vipergen
11.2.2.3
M (de novo)
b
Melkko et al. 2010
[65]
4,000
DNA conjugate (2)
Bcl-xL
0.93
Philochem AG
11.2.2.1
0.68
M (de novo)
c
Kleiner et al. 2010
[77]
13,824
DNA templated
Src kinase
Harvard University
11.2.2.3
Mannocci et al.
2010 [62]
8,000
DNA conjugate (2)
Trypsin
3.0 nM (based on lead
structure)
c
Philochem AG
11.2.2.1
Buller et al. 2011
[116]
1 million
DNA conjugate (3)
CAIX
0.5
M (based on lead
structure)
c
ETH Z urich/Philochem
AG
11.2.2.1
Universit
´
ede
Strasbourg-CNRS
(ISIS)
Daguer et al. 2011
[100]
62,500
Dual pharmacophore
Carbonic anhydrase
0.3
M (based on lead
structure)
11.2.3
Ciobanu et al.
2011 [99]
37,485
Dual pharmacophore
DC-SIGN
0.127
M (based on
lead structure)
Universit´ede
Strasbourg-CNRS
(ISIS)
11.2.3
Leimbacher et al.
2012 [66]
30,000
DNA conjugate (2)
IL2
2.5
M (de novo)
b
ETH Z urich/Philochem
AG
11.2.2.1
Source:
From [44], with permission of The Royal Society of Chemistry.
a
A number in parentheses indicates the number of different building blocks and coding regions used for library construction.
b
K
D
measurements by fluorescence polarization.
c
IC
50
measurements.
d
Possible hydrolysis or alcoholysis products with about 7 nM potency have been reported [57].
