Biomedical Engineering Reference
In-Depth Information
(a)
(b)
FIGURE 10.2
(a) Example of one LOL. Each library within an LOL shares the same number
of diversity positions, identical building block side-chain functionalities, and the same number
of compounds. (b) Core scaffolds of small-molecule synthetic combinatorial libraries included
in the scaffold ranking plate of the Torrey Pines Institute for Molecular Studies.
numerous small-molecule libraries and discover novel active compounds for a
wide range of therapeutic applications [68,69]. Comparison of the combinatorial
libraries with drugs using molecular properties showed that combinatorial libraries
have a different degree of overlap with the property space of drugs. In the same
study, quantitative methods were used to demonstrate, the increased structural and
