Biomedical Engineering Reference
In-Depth Information
SCHEME 9.17
Synthesis of a skeletally-diverse library, exploiting metal-catalyzed cycloiso-
merizations of an acyclic enyne: (a) Pd(PPh
3
)
2
(OAc)
2
(5 mol%), C
6
H
6
, 44%; (b) [Cp
∗
RuCl
2
]
n
(5 mol%), COD (5 mol%), ethene, toluene, 77%; (c) Grubbs's first-generation catalyst (3
mol%), ethylene, CH
2
Cl
2
, 97%.
