Biomedical Engineering Reference
In-Depth Information
SCHEME 9.14
Branching pathways from an allene-containing tryptophan derivative: (a)
NaH, 1-bromobut-2-eyne, DMF; (b) R
2
CHO, TFA, CH
2
Cl
2
or MeOH; (c) 20 mol% AgNO
3
,
acetone, 56 to 72%; (d) but-2-ynoic acid, isobutyl chloroformate, NMM, THF; (e)
w, 225
â—¦
C,
DMF; (f) Mo(CO)
6
, DMSO, PhMe; (g) Boc
2
O, DMAP; (h) 5 mol% [Rh(CO)
2
Cl]
2
,CO
(1 atm), DCE.
