Biomedical Engineering Reference
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SCHEME 9.12 Complementary metal-catalyzed branching pathway: 80 ,Co 2 (CO) 8 ,
Et 3 NO-NH 4 Cl, benzene; 81 , 10 mol% Pd(PPh 3 ) 2 (OAc) 2 , benzene, 80 C; 82 ,
10 mol% CpRu(MeCN) 3 PF 6 , acetone; 83 , NaH, toluene; 84 , 10 mol% NaAuCl 4 , MeOH;
85 , 10 mol% Hoveyda-Grubbs's second-generation catalyst, CH 2 Cl 2 ; 86 , 4-methyl-1,2,4-
triazoline-3,5-dione, CH 2 Cl 2 .
to prepare the allene-containing tetrahydro-
-carbolines 93 , which were subjected
to Ag-catalyzed cyclization (
97 ). Acylation gave the allenyl-ynes 99 which were
subjected to cyclocarbonylation (
+
100 ).
Comer et al. have developed a branching pathway that exploits reactions between
alternative pairs of functional groups in the substrates (Scheme 9.15) [31]. The nitro
98 ), and thermal [2
2] cycloaddition (
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