Biomedical Engineering Reference
In-Depth Information
SCHEME 8.12
Synthesis of a 2070-member library of macrolactones based on scaffold
67
and assembled by RCM from precursor
66
.
the synthesis of a library of resorcylic acid lactones analogues of radicicol, pochonin
C with kinase inhibitory activity [87], macrosphelides [88], and dictyostatin [89].
8.5.3 Diversification on Macrolactam Scaffolds
Marcaurelle and co-workers reported the structurally divergent exploitation of the
eight stereoisomers of amino alcohol
80
(Scheme 8.15) in the construction of
four types of macrocycles, 81-84, with the goal of building a library of stereo-
chemically and chemically diverse structures. Scaffolds were obtained using four
SCHEME 8.13
Synthesis of a library of analogs of the epothilones using solid-phase chem-
istry.
