Biomedical Engineering Reference
In-Depth Information
SCHEME 7.38 Catalytic enantioselective Suga-Ibata reactions and diastereoselective enolate alkylation (couple phase) and subse-
quent Staudinger-type reductive cyclizations (pair phase). Reagents and conditions: (i) o -azide-substituted benzaldehydes, Al-complex
276 ,3 A MS, DCM; (ii) o -azide-substituted benzyl bromides, BEMP or BTPP, tetrabutylammonium iodide, NMP; (iii) PMe 3 ,DBU,
toluene/H 2 O/dioxane; (iv) BEMP or BTPP, electrophiles; (v) TMSOK, THF; (vi) PyBrOP, R 4 NH, DIEA, DCM.
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