Biomedical Engineering Reference
In-Depth Information
SCHEME 7.38
Catalytic enantioselective Suga-Ibata reactions and diastereoselective enolate alkylation (couple phase) and subse-
quent Staudinger-type reductive cyclizations (pair phase). Reagents and conditions: (i)
o
-azide-substituted benzaldehydes, Al-complex
276
,3 A MS, DCM; (ii)
o
-azide-substituted benzyl bromides, BEMP or BTPP, tetrabutylammonium iodide, NMP; (iii) PMe
3
,DBU,
toluene/H
2
O/dioxane; (iv) BEMP or BTPP, electrophiles; (v) TMSOK, THF; (vi) PyBrOP, R
4
NH, DIEA, DCM.