Biomedical Engineering Reference
In-Depth Information
O
O
R
OH
Me
R
O
N
O
N
H
H
O
N
O
R
R
172
R'
179
R'
Linkers:
I
,
II
,
IV
i, ii or iii
173
i, ii
Linker:
I
ii
Linker:
III
O
O
O
R
O
Me
Me
N
O
Me
O
NH
i, iii
i
O
N
Me
OH
R
Linkers:
II, IV
H
O
R
R
171
Me
178
Me
174
i, iii
i, ii
Linkers:
II, IV
iii
Linkers:
I
,
II, IV
Linker:
II
Linker:
III
i, ii or iii
O
O
R
O
O
N
N
O
Me
HN
O
O
R
H
O
H
R
R
1
75
O
N
O
R'
R'
H
Me
180
R
177
176
R'
R'
SCHEME 7.24
Synthesis of several diverse compounds by Diels-Alder reaction. Reagents and conditions: (i) diene, 0.1 M
n-
Bu
4
NIO
4
, DCM,
rt, 1 h; (ii) 50% TFA/DCM, rt, 30 min; (iii) 0.1 M TBAF, THF, rt, 30 min.
