Biomedical Engineering Reference
In-Depth Information
O
O
O
R
NH
2
O
R
NO
2
R
NO
2
O
H
H
H
H
H
HO
O
O
NH
O
N
N
i
iii, iv
O
O
O
Linker:
III
Linker:
I
N
167
170
166
N
N
ii, i
iii, i
Linker:
III
Linker:
II
O
N
O
R
O
H
N
H
H
R
O
H
H
N
N
O
O
O
O
169
168
SCHEME 7.23
Conversion of cycloadduct precursor into four acyclic and heterocyclic derivatives. Reagents and conditions: (i) 50%
TFA/DCM, rt, 30 min; (ii) SnCl
2
·
2H
2
O, DIEA, NMP, rt, 2 h; (iii) SnCl
2
·
2H
2
O, NMP, rt, 16 h; (iv) 0.01 M TBAF, THF, rt, 30 min.
