Biomedical Engineering Reference
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SCHEME 7.12 Synthesis of bi- and tricyclic heterocycles from tetracyclic template.
Reagents and conditions: (i) Yb(OTf) 3 , MeCN or PhCN, rt, 16 h; (ii) BuNH 2 , THF, rt, 24
h; (iii) Et 2 NH, Yb(OTf) 3 , THF, rt, 16 h; (iv) PhNCO, toluene, rt, 16 h.
7.2.1.2 Multiple Core Structures This section is dedicated to the synthesis of
multiple-core structures using a strategy based on transformation of a common pre-
cursor to structurally unrelated skeletons (multiple-core structures) in a few reaction
steps. The diversity of such libraries is generally higher than in those based on one
core structure.
7.2.1.2.1 Nitrogen Heterocycles DOS of three different nitrogenous heterocyclic
compounds started from a sulfone linker which enabled traceless release of the
products [33]. The synthesis started with S-alkylation of sulfinate resin yielding
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