Biomedical Engineering Reference
In-Depth Information
SCHEME 7.11
Synthesis of three different skeletons containing thiazole core structures. Reagents and conditions: (i) R
2
CH
2
COR
3
,
AlCl
3
,
w, MeCN, 150
◦
C; (ii)
m
CPBA, DCM, rt; (iii) R
4
R
5
NH, TEA, THF, 60
◦
C; (iv) R
2
NCO, DIEA,
w, DMSO, 150
◦
C; (v) NaH,
DMF, rt; (vi) R
3
X; (vii) R
4
R
5
NH, TEA, DCM, 40
◦
C; (viii) R
2
CH
2
SO
2
Cl,
t-
BuOLi, DCM, rt; (ix) R
3
OH, DIAD, PPh
3
,THF,rt.