Biomedical Engineering Reference
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SCHEME 5.24 Heck-aza-Michael domino sequence.
TABLE 5.15 Representative Sultam Analogs 63 Obtained from the Reaction Sequence
Shown in 5.24
Entry
R 1
R 2
R 3
Yield (%)
1
H
i -Pr
OMe
63a ,44
2
H
c -Hex
Me
63b ,29
3
H
Ph
OH
63c ,35
4
H
3-OMe-Ph
OEt
63d ,22
5
F
Bn
OMe
63e ,75
6
F
n -Oct
OEt
63f ,54
7
F
c -Pent
OEt
63g ,87
8
F
t -Bu
OEt
63h ,46
9
CF 3
i -Pr
OEt
63i ,50
10
CF 3
c -Hex
OMe
63j ,51
11
CF 3
c -Hex
OH
63k ,46
12
CF 3
Bn
OH
63l ,44
SCHEME 5.25 Double-Heck coupling derived sultams 65 .
 
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