Biomedical Engineering Reference
In-Depth Information
SCHEME 5.11
Nucleophilic substitutions of sulfoxide
28
to give heterocycles
29
.
TABLE 5.8 Tetracyclic Library 29
Entry
Nu
Yield (%)
1
Pyrrolidine
29a
,98
2
Aniline
29b
,60
3
SEt
29c
,55
4
SBn
29d
,87
5
O
n
-Bu
29e
,80
6
OPh
29f
,60
SCHEME 5.12
Oxidation/IEDDA domino sequence to produce of 1,4-benzoxazines
35
.
