DOMINO REACTIONS IN LIBRARY SYNTHESIS - Diversity-Oriented Synthesis - page 145

TABLE 5.2 Select Members of an Isoquinolone-Carboxamide Library Based on
Scaffold 8

R 1 Entry Amine Product, Yield (%)

1 n -Bu 8a ,82

2 n -Bu 8b ,88

3 c -Pr 8c ,50

4 c -Pr 8d ,67

5 c -Hex 8e ,83

6 c -Hex 8f ,90

7 Bn 8g ,54

8 Bn 8h ,90

9 3,4-Cl 2 -Bn 8i ,77

10 3,4-Cl 2 -Bn 8j ,75

11 3,4-(OMe) 2 -Bn 8k ,39

12 3,4-(OMe) 2 -Bn 8l ,61