Biomedical Engineering Reference
In-Depth Information
Table 2
Characteristics and advantages of Nannochloropsis as a green cell factory for CBP-SE
Nannochloropsis spp.
Chlamydomonas reinhardtii
Synechocystis sp. PCC 6803
Genetic background
Clear
Tiny genome size (20 * 30 Mb)
Simple genome structure and organization
Transformation possible [
61
-
63
]
Clear
Clear
Tiny genome size, (3.6 Mb) [
67
]
Simple genome structure and organization
Routine genetic manipulation [
68
,
69
]
Large genome size (* 120 Mb)
[
13
]
Complex genome structure and
organization
Routine genetic manipulation
[
64
-
66
]
Growth rate
Rapid (outdoor and lab conditions)
Rapid (lab condition)
Rapid (lab condition)
Stress tolerance
Tolerates high CO
2
content [
70
]
when fed flue gases
Tolerance to variable outdoor environments
Sensitive to high CO
2
content
Sensitive to variable outdoor
environments
Sensitive to high CO
2
content
Sensitive to variable outdoor environments
Water source
Low water-quality requirement
Freshwater, seawater, and wastewater
High water-quality requirement
Freshwater
Low water-quality requirement
Freshwater
Biomass productivity
High [
70
]
Low
High
Metabolites
Enormous diversity of biosynthetic
pathways [
15
,
17
]
High oil productivity
Produce of high-value
co-products [
16
]
Simple biosynthetic pathways
Low oil productivity
No co-products such as DHA,
astaxanthin etc.
Relatively simple biosynthetic pathway
Low oil productivity
No co-products such as DHA, astaxanthin
etc.
Post-translational
modification
Yes
Yes
No
Cultivation systems
Large-scale cultivation
demonstrated in variable
climate and areas of China,
USA, Israel
No outdoor cultivation system
Outdoor cultivation system remains to be
demonstrated
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