Biomedical Engineering Reference
In-Depth Information
Establishing Oleaginous Microalgae
Research Models for Consolidated
Bioprocessing of Solar Energy
Dongmei Wang, Yandu Lu, He Huang and Jian Xu
Abstract Algal feedstock is the foundation of the emerging algal biofuel industry.
However, few algae found in nature have demonstrated the combination of high
biomass accumulation rate, robust oil yield and tolerance to environmental
stresses, all complex traits that a large-scale, economically competitive production
scheme demands. Therefore, untangling the intricate sub-cellular networks
underlying these complex traits, in one or a series of carefully selected algal
research models, has become an urgent research mission, which can take
advantage of the emerging model oleaginous microalgae that have already dem-
onstrated small, simple and tackleable genomes and the potential for large-scale
open-pond cultivation. The revolutions in whole-genome-based technologies,
coupled with systems biology, metabolic engineering and synthetic biology
approaches, would enable the rational design and engineering of algal feedstock
and help to fill the gaps between the technical and economical reality and the
enormous potential of algal biofuels.
Keywords Biofuels
Functional genomics
Oil-producing algae
Research
models
Synthetic biology
Systems biology
Dongmei Wang and Yandu Lu have contributed equally to this work.
D. Wang
Y. Lu
J. Xu (
)
CAS Key Laboratory of Biofuels, Shandong Key Laboratory of Energy Genetics,
BioEnergy Genome Center, Qingdao 266101, Shandong, China
e-mail: xujian@qibebt.ac.cn
H. Huang
State Key Laboratory of Materials-Oriented Chemical Engineering,
College of Biotechnology and Pharmaceutical Engineering,
Nanjing University of Technology, Nanjing 210009, China
&
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