Biomedical Engineering Reference
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20
(a)
125
I-IGF-I
Unlabel IGF-I competitor (Bhakta et al. 2000)
Unlabel IGF-II competitor (Bhakta et al. 2000)
15
10
Numerical solution represents competition by unlabel IGF-I
Numerical solution represents competition by unlabel IGF-II
5
0
0
50
100
150
200
Unlabeled IGF (nM)
40
(b)
125
I-IGF-II
Unlabel IGF-I competitor (Bhakta et al. 2000)
Unlabel IGF-II competitor (Bhakta et al. 2000)
30
Numerical solution represents competition by unlabel IGF-I
20
10
Numerical solution represents competition by unlabel IGF-II
0
0
50
100
150
200
250
300
350
Unlabeled IGF (nM)
FIGURE 11.13
The determination of
K
D
11
,
K
D
12
,
K
D
21
,
K
D
22
,
c
b
BP
10
, and
c
b
BP
20
using the
experimental data of Bhakta et al. [29], (a) Competition of unlabeled IGF-I
and -II with
125
I-IGF-I for binding to bovine articular cartilage; (b) Competi-
tion of unlabeled IGF-I and -II with
125
I-IGF-II for binding to bovine articular
cartilage.
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