Biomedical Engineering Reference
In-Depth Information
20.8 CONCLUSIONS
Development of thin solid fi lms based on self-assembling of amphiphiles by bio-
mimetic approaches has immense potential in controlling the biological interac-
tions. The composition as well as the processing conditions regulates the physical
properties of the lipid TSF. This further regulates the integrity of the supported
TSF. Calcifi cation, protein adsorption, as well as blood cell adhesion and activa-
tion is minimal on these surfaces. Incorporation and lateral stabilization of the
proteins as well as other macromolecules into the TSF gives immense opportu-
nity for controlled ligand supplementation.
ACKNOWLEDGMENTS
We express our sincere thanks and gratitude for the fi nancial support by the DST
and CSIR as well as Director SCTIMST, and Head BMT Wing for providing the
facilities.
REFERENCES
1. Bryce MR , Petty CM . 2002 . Electrically conductive Langmuir - Blodgett fi lms of
charge- transfer materials . Nature 374 : 771 - 776 .
2. Ng CY , Chen TP , Sreeduth D , Chen Q , Ding L , Du A . 2006 . Silicon nanocrystal - based
non - volatile memory devices . Thin Solid Films 504 ; 1 - 2 : 25 - 27 .
3. Robert G . 1990 . Langmuir - Blodgett Films , Plenum Press , New York .
4. Hayward JA , Chapman D . 1984 . Biomembrane surfaces as models for polymer design:
the potential for haemocompatibility . Biomaterials 5 : 135 .
5. Svedhem S , Dahlborg D , Ekeroth J , Kelly J , H ö ö k F , Gold J . 2003 . In Situ Peptide -
Modifi ed Supported Lipid Bilayers for Controlled Cell Attachment. Langmuir 19:
6730 .
6. Ishihra K , Aragaki R , Ueda T , Watanabe A , Nakabayashi N . 1990 . Reduced thrombo-
genicity of polymers having phospholipid polar groups. J Biomed Mater Res 24:
1069 .
7. Petty MC . 1992 . Possible applications for . Langmuir - Blodgett fi lms Thin solid fi lms
210 : 211 , 417.
8. Langmuir I . 1917 . The constitution and fundamental properties of solid and liquids. II.
Liquids . J Am Chem Soc 39 : 1848 .
9. Blodgett KB . 1935 . Films Built by Depositing Successive Monomolecular Layers on a
Solid Surface . J Am Chem Soc 57 : 1007 .
10. Harkins WD . 1952 . The physical Chemistry of surface fi lms , Reinhold , NY , 41 , 95.
11. Kuhner M , Tampe R , Sackmann E . 1994 . Lipid mono - and bilayer supported on poly-
mer fi lms: composite polymer-lipid fi lms on solid substrates . Biophys J 67 ( 1 ): 217 - 226 .
12. Boxer SG . 2000 . Molecular transport and organization in supported lipid membranes .
Current Opinion in Chemical Biology 4 : 704 - 709 .
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