Biomedical Engineering Reference
In-Depth Information
TABLE 19.1. Early Study Results on the Stability of Cord Blood at Temperature and Time
Time
Temp
24 hr
48 hr
7 days
14 days
4 ° C
12.5 + 3.5
32.7 + 4.2
45.5 + 2.8
82.7 + 4.5
35 ° C
16.5 + 2.8
20.4 + 4.4
53.6 + 3.8
100
40 ° C
45.4 + 6.7
77.9 + 3.6
92.3 + 4.9
100
Mean Fragility (% hemolysis in 0.45% NaCl) with Standard deviation (N = 40)
Time
Temp
24 hr
48 hr
7 days
14 days
4 ° C
0.33 + .18
0.32 + .18
0.27 + .08
0.28 + .17
35 ° C
0.32 + .06
0.29 + .08
0.24 + .04
—
40 ° C
0.16 + .02
0.09 + .01
—
—
Mean Oxyhemoglobin (mmole/ml) with Standard deviation (N = 34)
Time
Temp
24 hr
48 hr
7 days
14 days
4 ° C
6.06 + .86
6.33 + .73
7.09 + .79
9.64 + 1.9
35 ° C
4.59 + .57
7.63 + .84
10.3 + 2.6
—
40 ° C
10.5 + 1.3
13.7 + 2.5
—
—
Mean Plasma hemoglobin (mg/ml) with Standard Deviation (N = 36)
and non-immunological reactions. The fi ndings of the research showed that there
was not a single case of immunological or non-immunological reaction noted
from 1999 [Bhattacharya et al. (28)], when this blood was fi rst transfused, to 2006,
when this phase of the study ended. This indicated the safety potential of cord
blood.
Following the publication of the fi rst report of this study in 2001, there was a
subsequent report on the safe use of cord blood to combat pediatric anemia in
Africa [Hassall et al. (29)]. However, it must be pointed out that the use of cord
blood was actually reported much earlier [Halbrecht (30)], in fact, before the
invention of the RH system and the introduction of modern screening proce-
dures. There were no blood bank services at that time and practically no screening
for infection and its transmission. Moreover, the study occurred before the inven-
tion of acid citrate dextrose (ACD) solution in 1943, which reduces the volume
of anticoagulant, permits transfusion of greater volumes of blood, and allows
longer-term storage. But in spite of these drawbacks, the study reported that cord
blood could be safely used as a substitute for peripheral blood for performing
transfusions.
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