Biomedical Engineering Reference
In-Depth Information
17
ORTHOPEDIC INTERFACE
TISSUE ENGINEERING: BUILDING
THE BRIDGE TO INTEGRATED
MUSCULOSKELETAL
TISSUE SYSTEMS
Helen H. Lu, Kristen L. Moffat, and Jeffrey P. Spalazzi
Biomaterials and Interface Tissue Engineering Laboratory, Department of
Biomedical Engineering, Columbia University, New York, New York
Contents
17.1 Overview
589
17.2 Design Considerations in Interface Tissue Engineering
590
17.3 Mechanism of Interface Regeneration: Role of Heterotypic
Cellular Interactions
593
17.4 Structure - Function Relationship at the Interface
596
17.5 Multi - Phased Scaffold Design for Interface Tissue Engineering
599
17.6 Summary and Challenges in Interface Tissue Engineering
603
Acknowledgments
603
References
604
17.1 OVERVIEW
Over the past two decades, the fi eld of tissue engineering has focused on formu-
lating and validating a consistent experimental methodology for ex vivo tissue
 
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