Biomedical Engineering Reference
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(a)
(b)
(c)
(d)
(e)
Figure 16.4.
Results of nano-HA/collagen/PLA composite scaffold in a rabbit model. (a) X-
ray result of defect immediately after implantation. (b) X-ray result after 12 weeks of post-
implantation, where double cortical bone was connected. (c) Decalcifi ed histology (Haema-
toxylin and Eosin or HE staining) at 8 weeks. (d) Histology (HE staining) at 12 weeks, with
double cortical bone was connected completely, bone marrow and new trabeculae bone was
formed in the vertex region. (e) Decalcifi ed histology (HE staining) at 12 weeks, compare with
(c) where more trabeculae bone was formed.
73
(See color insert.)
observation also indicated that within 12 weeks post-implantation, complete
healing occurred and double cortical bone was connected to the defect (Figure
16.4d). Spherical cells adhered to the pores of the scaffold and appeared at the
composite and new bone interface after eight weeks (Figure 16.4c). Trabeculae
and bone marrow fi lled up the gaps left behind by the resorbed material. Figure
16.4e shows more trabeculae bone replacing the implant at 12 weeks than at eight
weeks (Figure 16.4 c).
The nano-HA/collagen/PLA composite did not give rise to any acidic by-
products unlike pure PLA materials as the pH value of the culture media did not
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