Biomedical Engineering Reference
In-Depth Information
1.4
(a)
1.2
1
0.8
0
1
2
3
4
5
Time (months)
30
(b)
Cryogel II
20
Cryogel III
10
Cryogel I
0
0
5
10
15
20
25
30
Time (day)
Figure 14.15.
(a) Degradation ratio of Dextran-MA MG scaffold at incubation at 37 °C and
pH 7.4. The dextran-MA MGs were prepared from 5% dextran-MA solution at
20 °C. Repro-
duced from [Plieva et al., 2006c] with permission. (b) Weight loss of non-degradable (cryogel
I) and degradable (cryogel II and III) MGs. The MGs were dried in air to a constant weight and
then placed in vials containing 5 ml saline PBS buffer (pH 7.4) at 37 °C. At selected time inter-
val, the samples were removed from the medium, dried in the air overnight and weighted to
determine weight loss. Cryogel I represents the MGs consisting of 90wt% HEMA and 10wt%
HEMA-LLA. Cryogel II represents the degradable MGs consisting of 10wt% HEMA and 90wt%
HEMA-LLA-dextran. Cryogel III represents the degradable MGs consisting of 10wt% HEMA-
LLA and 90wt% HEMA-LLA-dextran. Reproduced from [Bolgen et al., 2007a] with permission.
−
comparison to the control, non-differentiated 3T3-L1 preadipocytes [Plieva
et al., 2006c].
The tissue-like elasticity and open porous structure of the MG scaffolds are
the unique properties of these materials. The size of pores, hydrophilic/hydropho-
bic balance and elasticity of pore walls can be varied to a large extent when pre-
paring the MGs' scaffolds for cell culture application. By introducing special
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