FUNDAMENTALS OF BIOMATERIALS AND BIOCOMPATIBILITY - Advanced Biomaterials: Fundamentals, Processing, and Applications - page 8

Centrosome with
pair of centrioles
Chromation (DNA)

(a)

Microtubule

Extracellular matrix

5 μ m

Nuclear pore
Nuclear envelope

Vesicles

Lysosome

Actin
filaments

Mitochondrion

Nucleolus

Peroxisome

Nucleus

Ribosomes
in cytosol

Golgi
apparatus

Intermediate
filaments

Plasma
membrane

Endoplasmic
reticulum

(b)

Biological cell

Nucleus

Protein molecules

Solid substrate

Figure 1.3. Schematic illustration showing the anatomy of an eukaryotic animal cell (a) [Re-
produced from Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts,
Peter Walter, Introduction to the Cells in “Molecular Biology of The Cell”.] and the fundamen-
tal mechanisms involved in biomaterial-cell interaction, established by the adsorbed proteins
(circles, boxes and triangles) with the integrin proteins of a biological cell (b) [Reproduced
from BD Ratner, AS Hoffman, FJ Schoen, JE Lemons, Biomaterials Science—An Introduction to
Materials in Medicine, 2 nd edition, Academic Press, New York, 2004.].