Biomedical Engineering Reference
In-Depth Information
Bone Proliferation
(a)
4.5
4
Day 4
Day 7
3.5
3
2.5
2
1.5
1
0.5
0
TNZT
Ti-6Al-4V
Samples
(b)
Bone Differentiation
60
Day 4
Day 7
50
40
30
Figure 9.17.
(a) Bone cell
proliferation and (b) Bone cell
differentiation results from the
fi rst test. [Sonia Samuel, (M.S.
Thesis, Dept of Mater. Sci. and
Eng., University of North Texas,
2007)]
20
10
0
TNZT
Ti-6Al-4V
Samples
DNA concentration, which is correlated to the cell number grown on the surfaces.
Studies of DNA were performed after three and six days of bone cell seeding. The
results are presented as shown in Figure 9.18. The ALP assays are used to measure
the ALP production per ng DNA for each sample used to indicate the bone cell
differentiation. It was observed that the TNZT samples allow for substantially
enhanced bone cell differentiation of bone marrow stem cells as compared to the
Ti-6Al-4V ELI control samples. In contrast, cell growth on TNZT samples is not
as good as those grown on control samples in this second set of experiments.
These results suggest that the laser deposited Ti-35Nb-7Zr-5Ta alloy promotes
the osteogenic potential of bone marrow stem cells compared to the Ti-6Al-4V
ELI alloy.
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