SCIENCE AND TECHNOLOGY INTEGRATED TITANIUM DENTAL IMPLANT SYSTEMS - Advanced Biomaterials: Fundamentals, Processing, and Applications - page 152

References
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Figure 5.5. Distribution of surface roughness of successfully implanted and clinically
biofunctioning materials.

but also to its macromorphologic nature [Schroeder et al., 1981; Rich et al., 1981;
Buser et al., 1991].
From an in vitro standpoint, the response of cells and tissues at implant
interfaces can be affected by surface topography or geometry on a macroscopic
basis [Schroeder et al., 1981; Buser et al., 1991], as well as by surface morphology
or roughness on a microscopic level [Rich et al., 1981; Murray et al., 1989]. These
characteristics undoubtly affect how cells and tissues respond to various types of
biomaterials. Of all the cellular responses, it has been suggested that cellular
adhesion is considered the most important response necessary for developing a
rigid structural and functional integrity at the bone/implant interface [Cherhoudi
et al., 1988]. Cellular adhesion alters the entire tissue response to biomaterials
[von Recum, 1990].
The effect of surface roughness (Ra: 0.320, 0.490, and 0.874

m) of the tita-
nium alloy Ti-6Al-4V on the short- and long-term response of human bone

μ